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Regie.ai vs Mailshake

A detailed comparison of Regie.ai and Mailshake. Find out which AI SDR solution is right for your team.

📌Key Takeaways

  • 1Regie.ai vs Mailshake: Comparing 6 criteria.
  • 2Regie.ai wins 1 categories, Mailshake wins 5, with 0 ties.
  • 3Regie.ai: 4.8/5 rating. Mailshake: 4.8/5 rating.
  • 4Overall recommendation: Mailshake edges ahead in this comparison.
Option A

Regie.ai

4.8

Generative AI platform for creating personalized sales content and automating outbound prospecting at scale

1 wins
View full review →
Option B

Mailshake

4.8

Sales engagement platform with AI-powered email writing, automated follow-ups, and phone dialer for multi-channel outreach

5 wins
View full review →

1

Regie.ai wins

0

Ties

5

Mailshake wins

Feature Comparison

CriteriaRegie.aiMailshakeWinner
Email Deliverability53Regie.ai
Personalization34Mailshake
Automation Level34Mailshake
CRM Integration45Mailshake
Ease of Use34Mailshake
Multi-channel Support34Mailshake

Detailed Analysis

Email Deliverability

Regie.ai

Regie.ai

Regie.ai's email deliverability capabilities

Mailshake

Mailshake's email deliverability capabilities

Comparing email deliverability between Regie.ai and Mailshake.

Personalization

Mailshake

Regie.ai

Regie.ai's personalization capabilities

Mailshake

Mailshake's personalization capabilities

Comparing personalization between Regie.ai and Mailshake.

Automation Level

Mailshake

Regie.ai

Regie.ai's automation level capabilities

Mailshake

Mailshake's automation level capabilities

Comparing automation level between Regie.ai and Mailshake.

CRM Integration

Mailshake

Regie.ai

Regie.ai's crm integration capabilities

Mailshake

Mailshake's crm integration capabilities

Comparing crm integration between Regie.ai and Mailshake.

Ease of Use

Mailshake

Regie.ai

Regie.ai's ease of use capabilities

Mailshake

Mailshake's ease of use capabilities

Comparing ease of use between Regie.ai and Mailshake.

Multi-channel Support

Mailshake

Regie.ai

Regie.ai's multi-channel support capabilities

Mailshake

Mailshake's multi-channel support capabilities

Comparing multi-channel support between Regie.ai and Mailshake.

Feature-by-Feature Breakdown

AI Agents (Auto‑Pilot)

Mailshake

Regie.ai

AI‑driven prospecting agents continuously scan intent sources, enrich contact data, prioritize leads, and generate personalized multi‑channel sequences without human input. The agents learn from engagement outcomes, adapting prompts and timing to maximize response rates, and hand off warm leads to reps for final conversion. Reduces manual research and sequencing time, allowing SDRs to focus on high‑value conversations.

Reduces manual research and sequencing time, allowing SDRs to focus on high‑value conversations

Mailshake

Mailshake's AI personalization engine goes far beyond simple mail merge functionality, utilizing advanced natural language processing to craft contextually relevant messages for each prospect. The system analyzes prospect data including job title, company size, industry, recent news, and social media activity to generate personalized opening lines, value propositions, and calls-to-action. The AI learns from engagement patterns across your campaigns, automatically identifying which personalization approaches resonate with different prospect segments and adjusting recommendations accordingly. This enables sales teams to send thousands of emails that feel individually crafted while spending a fraction of the time required for manual personalization. Achieve 2-3x higher response rates while reducing email creation time by 80% through intelligent, data-driven personalization at scale.

Achieve 2-3x higher response rates while reducing email creation time by 80% through intelligent, data-driven personalization at scale

Both Regie.ai and Mailshake offer AI Agents (Auto‑Pilot). Regie.ai's approach focuses on ai‑driven prospecting agents continuously scan intent sources, enrich contact data, prioritize leads, and generate personalized multi‑channel sequences without human input., while Mailshake emphasizes mailshake's ai personalization engine goes far beyond simple mail merge functionality, utilizing advanced natural language processing to craft contextually relevant messages for each prospect.. Choose based on which implementation better fits your workflow.

AI Dialer

Mailshake

Regie.ai

A built‑in parallel dialing engine that can place up to nine calls simultaneously, deliver AI‑generated call scripts, real‑time transcription, voicemail drops, and call scoring. Integrated with the AI Agents, the dialer automatically dials the highest‑intent contacts at the optimal moment. Increases call volume and connection rates while maintaining conversation quality.

Increases call volume and connection rates while maintaining conversation quality

Mailshake

Mailshake's multi-channel sequencing capability enables sales teams to orchestrate coordinated outreach across email, LinkedIn, and phone within a single automated workflow. Users can design sophisticated cadences that automatically transition between channels based on prospect engagement, ensuring no opportunity falls through the cracks. The platform intelligently spaces touchpoints to avoid overwhelming prospects while maintaining consistent presence throughout the buying journey. Each channel interaction is logged and synchronized, providing complete visibility into the prospect's engagement history regardless of where the conversation occurs. Increase prospect touchpoints by 3x and improve connection rates by engaging prospects on their preferred communication channels.

Increase prospect touchpoints by 3x and improve connection rates by engaging prospects on their preferred communication channels

Both Regie.ai and Mailshake offer AI Dialer. Regie.ai's approach focuses on built‑in parallel dialing engine that can place up to nine calls simultaneously, deliver ai‑generated call scripts, real‑time transcription, voicemail drops, and call scoring., while Mailshake emphasizes mailshake's multi-channel sequencing capability enables sales teams to orchestrate coordinated outreach across email, linkedin, and phone within a single automated workflow.. Choose based on which implementation better fits your workflow.

Signal Selling

Mailshake

Regie.ai

Real‑time intent detection monitors over 100 buyer signals (website visits, content consumption, firmographic changes). When a signal fires, the platform instantly adjusts outreach cadence, channel, and messaging to engage the prospect at the precise moment of interest. Ensures outreach is timely and relevant, dramatically improving reply and meeting rates.

Ensures outreach is timely and relevant, dramatically improving reply and meeting rates

Mailshake

The Lead Catcher feature automatically monitors all campaign responses and uses AI-powered sentiment analysis to identify and prioritize hot prospects requiring immediate attention. The system distinguishes between positive responses, objections, out-of-office replies, and unsubscribe requests, automatically routing each to appropriate workflows. Hot leads are flagged in real-time with mobile notifications, ensuring sales reps can strike while interest is high. The AI scoring algorithm considers multiple engagement signals including email opens, link clicks, reply sentiment, and website visits to generate a comprehensive lead score. Never miss a hot lead again with instant notifications and AI-powered prioritization that surfaces your most promising opportunities.

Never miss a hot lead again with instant notifications and AI-powered prioritization that surfaces your most promising opportunities

Both Regie.ai and Mailshake offer Signal Selling. Regie.ai's approach focuses on real‑time intent detection monitors over 100 buyer signals (website visits, content consumption, firmographic changes)., while Mailshake emphasizes lead catcher feature automatically monitors all campaign responses and uses ai-powered sentiment analysis to identify and prioritize hot prospects requiring immediate attention.. Choose based on which implementation better fits your workflow.

Data Enrichment & Contact Database

Mailshake

Regie.ai

Instant access to more than 220 million verified contacts, including mobile numbers, with continuous updates from leading data providers. Enrichment occurs automatically during prospecting, eliminating the need for separate data‑purchasing tools. Provides clean, up‑to‑date prospect data, reducing data‑staleness and lowering acquisition costs.

Provides clean, up‑to‑date prospect data, reducing data‑staleness and lowering acquisition costs

Mailshake

Mailshake's comprehensive deliverability suite addresses the critical challenge of ensuring outreach emails actually reach prospect inboxes. The platform includes automated email warming that gradually builds sender reputation, real-time spam score analysis that flags problematic content before sending, and domain health monitoring that alerts users to potential deliverability issues. The system also provides guidance on optimal sending volumes, authentication setup (SPF, DKIM, DMARC), and content best practices to maximize inbox placement rates across different email providers. Maintain 95%+ inbox placement rates and protect your domain reputation with proactive deliverability monitoring and optimization.

Maintain 95%+ inbox placement rates and protect your domain reputation with proactive deliverability monitoring and optimization

Both Regie.ai and Mailshake offer Data Enrichment & Contact Database. Regie.ai's approach focuses on instant access to more than 220 million verified contacts, including mobile numbers, with continuous updates from leading data providers., while Mailshake emphasizes mailshake's comprehensive deliverability suite addresses the critical challenge of ensuring outreach emails actually reach prospect inboxes.. Choose based on which implementation better fits your workflow.

Unified Multi‑Channel Workflow

Mailshake

Regie.ai

One platform orchestrates email, phone, LinkedIn, and social touches, synchronizes with CRMs (Salesforce, Outreach, Salesloft) and intent providers (6sense, ZoomInfo). Users design playbooks that the AI executes end‑to‑end, with full visibility into performance across channels. Eliminates tech‑stack bloat and gives a single source of truth for pipeline reporting.

Eliminates tech‑stack bloat and gives a single source of truth for pipeline reporting

Mailshake

Mailshake's analytics dashboard provides comprehensive visibility into campaign performance with granular metrics including open rates, click rates, reply rates, and conversion tracking across every touchpoint. The platform offers cohort analysis to compare performance across different prospect segments, A/B test results with statistical significance indicators, and team performance leaderboards for sales management. Users can drill down into individual sequence performance, identify bottlenecks in their cadences, and export detailed reports for stakeholder presentations. The dashboard also includes predictive analytics that forecast campaign outcomes based on early engagement signals. Make data-driven decisions with real-time insights that reveal exactly what's working and where to optimize your outreach strategy.

Make data-driven decisions with real-time insights that reveal exactly what's working and where to optimize your outreach strategy

Both Regie.ai and Mailshake offer Unified Multi‑Channel Workflow. Regie.ai's approach focuses on one platform orchestrates email, phone, linkedin, and social touches, synchronizes with crms (salesforce, outreach, salesloft) and intent providers (6sense, zoominfo)., while Mailshake emphasizes mailshake's analytics dashboard provides comprehensive visibility into campaign performance with granular metrics including open rates, click rates, reply rates, and conversion tracking across every touchpoint.. Choose based on which implementation better fits your workflow.

Strengths & Weaknesses

Regie.ai

Strengths

  • AI Agents (Auto‑Pilot): AI‑driven prospecting agents continuously scan intent sources, enrich contact data, prioritize leads, and generate personalized multi‑channel sequence...
  • AI Dialer: A built‑in parallel dialing engine that can place up to nine calls simultaneously, deliver AI‑generated call scripts, real‑time transcription, voicema...
  • Signal Selling: Real‑time intent detection monitors over 100 buyer signals (website visits, content consumption, firmographic changes). When a signal fires, the platf...
  • Data Enrichment & Contact Database: Instant access to more than 220 million verified contacts, including mobile numbers, with continuous updates from leading data providers. Enrichment o...
  • Unified Multi‑Channel Workflow: One platform orchestrates email, phone, LinkedIn, and social touches, synchronizes with CRMs (Salesforce, Outreach, Salesloft) and intent providers (6...

Weaknesses

  • Learning curve for advanced automation features - optimal configuration may require experimentation and iteration.
  • Data accuracy varies by region - international markets may have less comprehensive or current contact information.
  • AI-generated content requires human review to ensure accuracy and brand voice consistency.

Mailshake

Strengths

  • AI Email Personalization Engine: Mailshake's AI personalization engine goes far beyond simple mail merge functionality, utilizing advanced natural language processing to craft context...
  • Multi-Channel Sequencing: Mailshake's multi-channel sequencing capability enables sales teams to orchestrate coordinated outreach across email, LinkedIn, and phone within a sin...
  • Lead Catcher with AI Scoring: The Lead Catcher feature automatically monitors all campaign responses and uses AI-powered sentiment analysis to identify and prioritize hot prospects...
  • Email Deliverability Suite: Mailshake's comprehensive deliverability suite addresses the critical challenge of ensuring outreach emails actually reach prospect inboxes. The platf...
  • Advanced Analytics Dashboard: Mailshake's analytics dashboard provides comprehensive visibility into campaign performance with granular metrics including open rates, click rates, r...

Weaknesses

  • Learning curve for advanced automation features - optimal configuration may require experimentation and iteration.
  • Data accuracy varies by region - international markets may have less comprehensive or current contact information.
  • AI-generated content requires human review to ensure accuracy and brand voice consistency.

Industry-Specific Fit

IndustryRegie.aiMailshakeBetter Fit
SaaSRegie.ai’s high‑volume, AI‑driven outreach lets SaaS companies scale outbound campaigns across thousands of accounts without adding SDR headcount, delivering 3–5× reach while preserving personalized messaging that resonates with product‑focused buyers.Not specifiedRegie.ai
FinTechThe platform’s compliance‑focused email templates, GDPR‑aware data handling, and real‑time signal prioritization help FinTech firms meet strict regulatory standards while still delivering timely, relevant outreach to financially‑savvy prospects.Not specifiedRegie.ai
HealthcareHealthcare vendors benefit from Regie.ai’s secure data enrichment and HIPAA‑compatible handling, enabling them to target clinicians and administrators with highly personalized, compliant messaging at scale.Not specifiedRegie.ai
Real EstateReal‑estate teams can leverage AI Agents to continuously source new property owners, enrich listings with ownership data, and execute multi‑touch campaigns that adapt to market‑driven signals such as property listings or zoning changes.Commercial real estate brokers and property technology companies use Mailshake to systematically engage property owners, investors, and corporate tenants. The platform enables personalized outreach at scale that references specific properties, market conditions, and investment criteria, while multi-channel sequences ensure persistent follow-up on high-value opportunities.Mailshake
Enterprise SecuritySecurity providers often need rapid, high‑volume outreach to IT decision‑makers. Regie.ai’s parallel dialing and signal‑driven prioritization accelerate contact rates while maintaining strict data‑security protocols.Not specifiedRegie.ai
SaaS & TechnologyNot specifiedMailshake is particularly well-suited for SaaS and technology companies where outbound sales development is a critical growth engine. These organizations typically have well-defined ideal customer profiles, long sales cycles requiring multiple touchpoints, and the technical sophistication to leverage advanced automation features. The platform's ability to personalize outreach based on technographic data helps SaaS SDRs craft relevant messages that reference prospects' existing tech stacks and potential integration opportunities.Mailshake
Professional ServicesNot specifiedConsulting firms, agencies, and professional services organizations use Mailshake to scale business development efforts while maintaining the personalized, relationship-focused approach their industries demand. The platform enables partners and business development professionals to execute systematic outreach campaigns that feel personal, leveraging AI to reference industry-specific challenges and demonstrate relevant expertise without spending hours on individual email composition.Mailshake
Financial ServicesNot specifiedFinancial advisors, wealth managers, and B2B financial services providers leverage Mailshake to reach prospects with compliant, personalized outreach at scale. The platform's template management and approval workflows help ensure messaging meets regulatory requirements, while multi-channel sequences enable the persistent but professional follow-up that complex financial decisions require.Mailshake

Our Verdict

Regie.ai and Mailshake are both strong AI SDR solutions. Mailshake stands out for ai agents (auto‑pilot). Choose based on which specific features and approach best fit your workflow and requirements.

Choose Regie.ai if you:

  • You operate in SaaS
  • You prefer Regie.ai's approach to ai sdr
  • You prefer Regie.ai's approach to ai sdr
View Regie.ai

Choose Mailshake if you:

  • You need ai agents (auto‑pilot) capabilities
  • You need ai dialer capabilities
  • You operate in SaaS & Technology
View Mailshake

Need Help Choosing?

Get expert guidance on selecting between Regie.ai and Mailshake for your specific use case.

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Frequently Asked Questions

It depends on your specific needs. Regie.ai and Mailshake each have strengths in different areas. Compare features, integrations, and pricing to determine which is best for your use case.
In some cases, yes. Many teams use complementary tools together. Check if both platforms offer integrations or APIs that allow them to work together.
Both platforms offer different onboarding experiences. Regie.ai and Mailshake each have their own setup processes. Most users can get started with either within a few hours.
The main differences are in their approach, feature set, and target use cases. Review the comparison criteria above to see detailed breakdowns of how they differ.
For small teams, consider factors like ease of use, pricing tiers, and the specific features you need most. Both Regie.ai and Mailshake can work for small teams depending on your priorities.

Sources & Evidence

  • AI‑native autonomous prospecting agents that dynamically prioritize leads using real‑time intent signals and execute multi‑channel outreach without human intervention

    Source: Regie.ai’s patented AI‑agent technology (patent secured 2025) powers Signal Selling, enabling agents to act on over 100 intent triggers instantly; the platform generated $650K pipeline in four months for a security firm and $200K+ pipeline for Crunchbase with no additional headcount (sources 8,13,17).

  • AI-powered email copy generation with personalization at scale

    Source: Mailshake's AI engine generates personalized email subject lines and body copy based on prospect data, enabling users to maintain personalization across thousands of outreach emails without manual writing. The platform analyzes prospect information including company details, job titles, and industry context to craft messages that resonate with individual recipients. This differentiates Mailshake from basic email automation tools by combining AI content generation with sales automation in a single platform, allowing teams to achieve 2-3x higher response rates compared to generic templated outreach while reducing email composition time by up to 80%.

  • Regie.ai Raises $30M Series B to Scale AI‑Powered Sales Strategies, Introducing RegieOne Platform

    Source: PR Newswire - View source

  • New ROI Study from GTM Partners Shows How Regie.ai Delivers Meetings & Pipeline Using Autonomous AI Sales Agents

    Source: PR Newswire - View source

  • We Used Regie AI for 30 Days: Honest Review from a GTM Team

    Source: salesforge.ai - View source

  • Our Pricing | Pay for Impact & Outcomes, Not Access - Regie.ai

    Source: regie.ai - View source

  • In-depth Regie.ai Review: Is their personalization ... - SalesRobot

    Source: salesrobot.co - View source

Last updated: January 30, 2026

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